Unlimited multistability in multisite phosphorylation systems
نویسندگان
چکیده
منابع مشابه
Unlimited multistability and Boolean logic in microbial signalling
The ability to map environmental signals onto distinct internal physiological states or programmes is critical for single-celled microbes. A crucial systems dynamics feature underpinning such ability is multistability. While unlimited multistability is known to arise from multi-site phosphorylation seen in the signalling networks of eukaryotic cells, a similarly universal mechanism has not been...
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Multisite phosphorylation plays an important role in intracellular signaling. There has been much recent work aimed at understanding the dynamics of such systems when the phosphorylation/dephosphorylation mechanism is distributive, that is, when the binding of a substrate and an enzyme molecule results in the addition or removal of a single phosphate group and repeated binding therefore is requ...
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The phosphorylation of a substrate at multiple sites is a common protein modification that can give rise to important structural and electrostatic changes. Scaffold proteins can enhance protein phosphorylation by facilitating an interaction between a protein kinase enzyme and its target substrate. In this work we consider a simple mathematical model of a scaffold protein and show that under spe...
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1 Network Deficiency and Monostable Reaction Networks 1 1.1 Network deficiency . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.2 Applications of network deficiency . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.3 Strongly sign determined systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.4 Applications of strongly sign determined sys...
متن کاملThe geometry of multisite phosphorylation.
Reversible protein phosphorylation on multiple sites is a key regulatory mechanism in most cellular processes. We consider here a kinase-phosphatase-substrate system with two sites, under mass-action kinetics, with no restrictions on the order of phosphorylation or dephosphorylation. We show that the concentrations of the four phosphoforms at steady state satisfy an algebraic formula-an invaria...
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature08102